CBD Tolerance: here’s why you can’t build up a resistance

It's a rather basic concept to build a tolerance to anything. The human body is prone to adapting to substances and, as a result, lowering their efficacy over time.

The majority of people who use cannabidiol are informed that taking a consistent, daily dose is the key to receiving the best effects.

However, many people think that using CBD regularly will cause them to develop a tolerance to it and, as a result, require a higher dose every time.

In this blog, we’ll explain why this is not the case with CBD, and why you can’t develop a resistance to it.

Let’s start!


How does Tolerance develop?


The rate at which you develop tolerance to a substance differs significantly from person to person.

We all have different genetic structures, and our physiology is also different.

Tolerance to a certain dose of a substance can take two weeks for one individual and months for another.

Drugs that bind directly to our endocannabinoid receptors are the most common cause of tolerance (THC for example).

Long-term use triggers an inner response from the endocannabinoid system, and our bodies adjust to the compound's constant presence, necessitating a greater dose to produce the same effect.

Long-term THC use has been shown to increase tolerance, according to research. The euphoric effect of THC is due to its strong binding to the cannabinoid receptor CB1.

THC reduces the number of accessible cannabinoid receptors over time.

A 2012 study found that chronic THC users have fewer cannabinoid receptors than non-users, supporting this theory.

The same users returned to reduced dosages after a break from THC, and their cannabinoid receptor levels had restored to normal.


Why CBD doesn’t cause tolerance


CBD uniquely interacts with the endocannabinoid system compared to other substances found in the cannabis plant.

It binds to the CB1 and CB2 receptors indirectly instead of directly. CBD's neuroprotective effects are independent of CB1 receptor inhibition, according to a study

This means that the cannabinoid does not need to attach to the receptors directly to function. As a result, it is less sensitive to tolerance mechanisms in theory.

Instead, CBD can increase the affinity of specific receptors and promote the creation of endocannabinoids, which are essential for maintaining homeostasis through the ECS.

We’ll explain this mechanism known as 'Reverse Tolerance’ below.


Reverse Tolerance


Reverse tolerance, also known as drug sensitization, occurs when a smaller amount of something is required to have the same result.

Tolerance is the total opposite of this. A lower dose is required, and in some circumstances, the dose is gradually reduced.

CBD may cause reverse tolerance, according to certain studies.

Unlike THC, which acts as an endocannabinoid and can down-regulate the endocannabinoid system, CBD has the ability to boost endocannabinoid levels.

GABA and NMDA receptors respond to CBD and have been found to play a role in reverse tolerance.

As a result, users may discover that they need lesser dosages of CBD to achieve the same outcomes over time.



Find the right dosage for yourself


Because everyone's body is different depending on their genetic composition, determining the proper CBD dosage necessitates some personal experimentation.

Make sure that you are using the real CBD Oil, with a high percentage of CBD, and not a fake CBD oil that will bring you no benefits.

We’ll be happy to help you determine the right dosage for you.

Now that you know that you are not able to develop a resistance to CBD, head to the SHOP on our website, and order your first Gramina CBD Oil bottle.


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